DNR (Deoxyribonucleic Acid) and RNA (Ribonucleic Acid) oligonucleotides are short sequences of nucleotides that can be synthesized for various biological and medical applications.

DNA Oligonucleotides

DNA oligonucleotides are short single- or double-stranded DNA molecules. They are commonly used in:

• PCR (Polymerase Chain Reaction): Amplifying DNA sequences for various experiments.
• Gene Synthesis: Creating specific sequences for cloning, gene editing, or studying gene function.
• Hybridization Probes: Used in assays like Southern blotting to detect specific DNA sequences.
• Antisense Oligos: Designed to bind to a specific mRNA, blocking translation and modulating gene expression.

RNA Oligonucleotides

RNA oligonucleotides are typically single-stranded and are used in various applications:

• RNA Interference (RNAi): Small interfering RNAs (siRNAs) or microRNAs (miRNAs) to silence specific gene expressions.
• CRISPR-Cas9: Guide RNAs (gRNAs) used in gene editing.
• mRNA Research: Studying gene expression, RNA splicing, and mRNA translation.
• Therapeutic Applications: Developing mRNA-based vaccines and therapies.